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Tuesday, November 13 • 4:00pm - 4:30pm
Biologics and New Modalities: Building Better iPSC Models of Human Disease and Development

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Since their initial generation in 2007 human induced pluripotent stem cells (hiPSC) have been used to model human development and disease progression, for drug screening and for toxicology testing. It is now possible to reprogram a wide range of cell types allowing a greater diversity of hiPSC to be generated and increasing the availability of hiPSC containing either specific mutations or from subjects with diseases that do not have known genotype. However, the diverse genetic background of the human race has hampered the usefulness of iPSC. Currently, controls often consist of age and sex-matched non-affected subjects or non-affected family members. The use of the CRISPR (clustered regularly-interspaced short palindromic repeats)/Cas system can create isogenic cell lines that will serve as better controls and help eliminate effects that are due to genetic variance rather than a biological mechanism. At RUCDR/Infinite Biologics we have developed a high throughput, cost efficient workflow for generating hiPSC from many different types of source cells and using CRISPR/Cas9 to genetically these cell lines, creating isogenic lines. Using this strategy, we have generated pairs of iPSC lines that are footprint free, meet all of the criteria necessary to certify the cell lines as pluripotent and use to better understand mechanisms of human disease and development.

Speaker
avatar for Jennifer Moore

Jennifer Moore

Director, RUCDR Stem Cell, RUCDR Infinite Biologics
Dr. Jennifer Moore is the Director of Stem Cell Services and Technologies at RUCDR Infinite Biologics at Rutgers, the State University of New Jersey. Dr. Moore received her bachelor’s of science degree from the University of North Carolina at Charlotte in Chemistry and her Ph.D... Read More →


Tuesday November 13, 2018 4:00pm - 4:30pm
Omni Parker House Omni Parker House, Boston, MA 02108, USA
  • Location Press Room

Attendees (1)